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It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids can be administered. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems - Dennis Hill MD
ENDOCANNABINOID SYSTEM
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 gives us the buzz, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites.4 Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is better for buzz, and indica is better for healing. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids can be administered. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems. This is why Rick Simpson recommends twice daily doses of hemp oil extract (C. indica), for three months, in the case of cancer. Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. CBD hijacks the lipoxygenase pathway to directly inhibit tumor growth.5 As a side note, it has been discovered that CBD inhibits anandamide reuptake. This means that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.6 Coincidentally, it is not only CBD that is specifically cytotoxic to cancer cells, THC takes a different approach the task: THC achieves this wizardry by binding to protein receptors on a cancerous cell’s surface. Once attached, the THC induces the cell to make a fatty substance called ceramide, which prompts the cell to start devouring itself. “We see programmed cell death,” Velasco says. What’s more, noncancerous cells don’t make ceramide when they come into contact with THC. The healthy cells don’t die.7 Just for clarity, endogenous ceramide (a signaling sphingolipid) disrupts the mitochondrial function of making ATP (adenosine triphosphate), thus the cancer cell becomes energy starved. ATP is the energy donor for all essential cell functions. Once the mitochondria shut down, the cell dies.8 Endogenous ceramide’s day job is to speed destruction of already stressed or senescent cells. We seen now that in the presence of THC, ceramide senses cancer cells as stressed or senescent, thus speeding their death. 8 Before leaving this topic it is important that we differentiate between plant based ceramide (phytosphingosine) and mammalian ceramide (endogenous sphignosine). Plant ceramide has a slightly different molecular structure but very different bioactivity. Ingested, it is a moisturizing lipid that supports the skin (stratum corneum) enhancing the moisture barrier that keeps epidermis from drying out. This is good, you should get some. I tried it and liked it. -Dennis Hill |
THC has shown to have a wide range of medical benefits associated to it. THC is most associated with the high and Euphoria feeling when using cannabis. THC has very high psychoactive characteristics associated to it typically ranging from 5 – 25 percent. Over medicating with THC can cause adverse side effects. Side effects including disorientation and even hallucinations. Additional but uncommon side effects studied have shown depression , anger , anxiety , and even short term memory loss.
Studies have show THC’s particular medicinal values:
Studies have show THC’s particular medicinal values:
- Helps with controlling pain
- Helps with relaxation
- Suppresses pain from nerve damage
- Helps reduce risk of nerve damage
- Helps control anxiety
- Suppresses muscle spasms and convulsions
- Helps control certain cancers
- Helps with nausea
- Slows inflammation
- Helps fight free radicals in the blood stream
- Encourages eating and appetite stimulation
- Stimulates new growth in nerve tissue
- Relieves chronic eye pressure and pain caused from glaucoma and other eye disorders
There is very little CBN present in fresh marijuana plants. The more CBN the less THC, medical cannabis containing high levels can also indicate its age and improper handling of medicine. High CBN levels also have shown undesirable symptoms like confusion, lightheadedness, and acts as a weak agonist of the cannabinoid receptors. CBN have a mildly psychoactive characteristics associated to it.
Studies have show CBN’s particular medicinal values:
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CBG are not found to much in medicinal cannabis but more commonly found in higher concentrations of hemp. CBG have no psychoactive characteristics associated to it.
Studies have show CBG’s particular medicinal values:
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Very little is known about CBC however research has shown to have valuable medicinal properties. CBC has no psychoactive characteristics associated to it.
Studies have show CBC’s particular medicinal values: Helps with controlling pain Stops growth of Fungi Slows inflammation Stimulates bone growth Encourages cell growth Stops growth of bacteria Assists in contraction of blood cells |
What is cbd? |
what is thc? |
Medicinal Properties
First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of CBD and THC, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for profound healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for its matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids are therapeutic. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
~Dennis Hill
First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of CBD and THC, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for profound healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for its matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids are therapeutic. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
~Dennis Hill
AIDS IS EASILY CURABLE WITH CANNABIS/HEMP EXTRACTS/OILS. PLUS, IF THE OIL WAS AVAILABLE, MOST DRUG USERS WOULD SIMPLY SWITCH TO THE HARMLESS OIL ANYWAY. PLUS, THE OIL CAN HELP TREAT ALL ADDICTIONS THEY SUFFER FROM ETC. JB - RICK SIMPSON FB.
aIds in humans & aids in animals
HIV spreads by infecting and ultimately killing immune cells.
However, the researchers observed higher levels of healthy immune cells in animals that received THC – something they noticed in a previous study as well.
The results were not what her team would’ve predicted, Dr. Molina explains.
“When we started the study, we thought it was going to increase viral load, we thought it was going to decrease lymphocyte counts much more dramatically,
ANd we did not see that. If anything, it looks like there might be some beneficial immunomodulation, particularly at the early stages of infection.”
Published last week in the journal AIDS Research and Human Retroviruses, researchers at Louisiana State University showed that daily doses of THC, marijuana’s main ingredient, have a number of beneficial effects in animal models of HIV.
In particular, THC given to monkeys over a 17-month period decreased damage to immune tissue of the gut, an important site of HIV infection. The team also found evidence that THC could do this by acting at the gene level.
“It adds to the picture and it builds a little bit more information around the potential mechanisms that might be playing a role in the modulation of the infection,” says Dr. Patricia Molina, head of the school’s Department of Physiology and lead author of the study.
HIV spreads by infecting and ultimately killing immune cells. However, the researchers observed higher levels of healthy immune cells in animals that received THC – something they noticed in a previous study as well.
In 2011, Dr. Molina and her colleagues found that monkeys treated with THC had lower levels of viral infection and better survival rates. They also experienced a spike in immune cells and less weight loss from the disease.
The results were not what her team would’ve predicted, Dr. Molina explains.
“When we started the study, we thought it was going to increase viral load, we thought it was going to decrease lymphocyte counts much more dramatically, and we did not see that. If anything, it looks like there might be some beneficial immunomodulation, particularly at the early stages of infection.”
Many have been skeptical of the use of marijuana in HIV/AIDS patients, since marijuana compounds are known to inhibit activity of the immune system.
But studies have shown that THC does not have a detrimental effect on viral load or immune cells, Dr. Molina says.
Now, researchers are trying to understand why marijuana might help, and develop new treatments that are more specific to its mechanisms.
“I think that there’s a lot of interest in trying to understand the specific receptor-mediated events that result from marijuana. And particularly, to focus on the CB2 receptor.”
Marijuana’s effect on the immune system is mostly due to its action on CB2 receptors, one of the two receptors that THC binds to. On the other hand, CB1 receptors are responsible for the high.
“There’s quite a bit of interest in trying to understand whether what we see as a immunomodulatory effect is mediated exclusively by the CB2 receptor,” Dr. Molina continues. “And if so, could that potentially lead to the development of agonists specific to the receptor that could have the same beneficial effects.”
A study published in 2013 by a Harvard University team found that CB2 activation may also prevent HIV from damaging the brain.
The study received funding from the National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA)
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According to new research published in the medical journal PLoS One - cannabinoids actually fight the HIV virus in late-stage AIDS patients. The study found that cannabinoid receptors are triggered by marijuana-like compounds and can actually block the spread of the HIV virus throughout the body
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Did I mention I am 99% cancer free? Thanks to my "medication". Hemp oil works but you have to believe.....I believe....tc - https://twitter.com/tommychong/status/224651609651675136
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Dennis Hill's Story: Beating Prostate Cancer With Cannabis OilBy: Dennis Hill
10-20-2013 "Three years ago, after a prostate biopsy, I was given the diagnosis of aggressive Stage III adenocarcinoma. I didn’t know what to do. The urologist made appointments for me to start radiation, and maybe chemo. Then a friend told me cannabis cures cancer. It just so happened that the first human trials of cannabis treatment of astrocytomas (inoperable brain cancer), were published with encouraging results. So I decided; rather than die from the medical treatment, I would do the cannabis cure. Now… where to get some. There was no dispensary in the area, but a friend made me cannabis butter, so I took that, up to tolerance. In three months the primary cancer was gone, only minor metastatic lesions were left. At that point I found a supplier for Rick Simpson oil and killed off the metastases in the next three months. Now I just take a maintenance dose of locally produced hash oil that is 1:1 THC:CBD with about a 30% potency. This will certainly keep me clear of cancer, anywhere, for ever. My point in telling this story is the fact that in the face of advanced aggressive cancer, all I had was very weak cannabutter, but it was enough to eliminate the primary tumor. Now there are strains of 95% THC. But is this necessary? If you have cancer and want to pursue the cannabis treatment, any at all will be good. More important than extreme potency, is balance between THC and CBD. If you can get high potency, great. If not, common potencies will work perfectly. Dennis Tells His Story Finally, if you choose cannabinoid treatment, start small, then increase dosage as rapidly as tolerable. To kill cancer you have to hit it hard, be conscientious about your treatment. Cannabis does no harm to the body, it is a metabolic support for the immune system." -Dennis Hill |
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Dennis Hill's Medical Records
Rick SIMPSON LETS THE GENIE OUT THE BOTTLE
"HEMP OIL CURES CANCER" !
SNOW BALLING EFFECT CAUSES;
"23 Legal Medical Marijuana States and DC OPEN UP"
BIGGEST MEDICAL MARIJUANA DISPENSARY IN USA
"HARBOURSIDE HEALTH CENTRE IN LA"
DOCUMENTARY
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